P38α inhibitor 4
P38α inhibitor 4 (compound 10) is a selective and allosteric p38α inhibitor with an IC50 value of 1.2 μM. p38α inhibitor 4 exhibits no activity against p38β, p38γ, and p38δ[1].
Product Specifications
CAS Number
1262406-08-5
UNSPSC
12352005
Target
P38 MAPK
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/p38α-inhibitor-4.html
Solubility
10 mM in DMSO
Smiles
O=C1C=C(C(F)(F)F)C2=C(NN=C2C3=CC(C(F)(F)F)=CC=C3)N1
Molecular Formula
C14H7F6N3O
Molecular Weight
347.22
References & Citations
[1]ACS Chem. Biol., Article ASAP
 DOI: 10.1021/cb1002619
 Publication Date (Web) : November 23, 2010|[2]Kenneth M Comess, et al. Discovery and characterization of non-ATP site inhibitors of the mitogen activated protein (MAP) kinases. ACS Chem Biol. 2011 Mar 18;6 (3) :234-44.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
P38α
Available Sizes
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