DHFR-IN-5

DHFR-IN-5 is a potent and orally active dihydrofolate reductase (DHFR) inhibitor with a Ki value of 0.54 nM for quadruple mutant Plasmodium falciparum DHFR. DHFR-IN-5 shows anti-malaria activity[1].

Product Specifications

CAS Number

[1142407-81-5]

UNSPSC

12352005

Target

Dihydrofolate reductase (DHFR)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/dhfr-in-5.html

Purity

99.27

Solubility

10 mM in DMSO

Smiles

O=C(CCC1=C(OCCCOC2=C(CC)N=C(N)N=C2N)C=CC=C1)O

Molecular Formula

C18H24N4O4

Molecular Weight

360.41

References & Citations

[1]Yuthavong Y, et al. Malarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised target. Proc Natl Acad Sci U S A. 2012 Oct 16;109 (42) :16823-8.