16,16-Dimethyl prostaglandin A1

16,16-Dimethyl prostaglandin A1 (di-Me-PGA1) is a prostaglandin analog that can inhibit DNA synthesis in Lewis lung carcinoma and B 16 amelanotic melanoma cells. 16,16-Dimethyl prostaglandin A1 also inhibits viral replication in both HSV and HIV-1 infection systems[1][2].

Product Specifications

CAS Number

[41692-24-4]

Product Name Alternative

Di-Me-PGA1

UNSPSC

12352211

Hazard Statement

H225-H319-H336

Target

DNA/RNA Synthesis; HIV; HSV

Type

Reference compound

Related Pathways

Anti-infection; Cell Cycle/DNA Damage

Applications

COVID-19-anti-virus

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/16-16-dimethyl-prostaglandin-a1.html

Solubility

10 mM in DMSO

Smiles

CCCCC(C)(C)[C@H](O)/C=C/[C@@H]1[C@H](C(C=C1)=O)CCCCCCC(O)=O

Molecular Formula

C22H36O4

Molecular Weight

364.52

Precautions

P210-P233-P240-P241-P242-P243-P261-P264-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P370+P378-P403+P233-P403+P235-P405-P501

References & Citations

[1]K V Honn, et al. Prostaglandin analogs as inhibitors of tumor cell DNA synthesis. Proc Soc Exp Biol Med. 1981 Apr;166 (4) :562-7. |[2]M Hughes-Fulford, et al. Effects of dimethyl prostaglandin A1 on herpes simplex virus and human immunodeficiency virus replication. Antimicrob Agents Chemother. 1992 Oct;36 (10) :2253-8.