Smad2/3-IN-1
Smad2/3-IN-2 (Compound 27) is an inhibitor for TGF-β-dependent Smad2/3 and IL-4-dependent STAT6 signaling pathway, with IC50s of 90 and 20 nM, respectively[1].
Product Specifications
UNSPSC
12352005
Target
Interleukin Related; STAT; TGF-beta/Smad
Type
Reference compound
Related Pathways
Immunology/Inflammation; JAK/STAT Signaling; Stem Cell/Wnt; TGF-beta/Smad
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/smad2-3-in-1.html
Solubility
10 mM in DMSO
Smiles
OC1=C(C(/C(C)=C/C[C@H](O)[C@H](C)[C@@H](C)OC2=O)=O)C(C2)=C(Cl)C(O)=C1
Molecular Formula
C18H21ClO6
Molecular Weight
368.81
References & Citations
[1]Seipp K, et al., Total Synthesis, Structure Reassignment, and Biological Evaluation of the Anti-Inflammatory Macrolactone 13-Hydroxy-14-deoxyoxacyclododecindione. J Nat Prod. 2024 Mar 31.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IL-4
Frequently Asked Questions
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