PARP11 inhibitor ITK7

PARP11 inhibitor ITK7 (ITK7) is a potent and selective PARP11 inhibitor. PARP11 inhibitor ITK7 can potently inhibit PARP11 with an IC50 value of 14 nM. PARP11 inhibitor ITK7 can be used for the research of cellular localization[1].

Product Specifications

CAS Number

[2411890-36-1]

Product Name Alternative

ITK7

UNSPSC

12352005

Target

PARP

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/parp11-inhibitor-itk7.html

Purity

99.70

Solubility

DMSO : 4 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1NC(CSC2=NC=CC=N2)=NC3=C1C=CC(C#CC)=C3C

Molecular Formula

C17H14N4OS

Molecular Weight

322.38

References & Citations

[1]Kirby, Ilsa T et al. A Potent and Selective PARP11 Inhibitor Suggests Coupling between Cellular Localization and Catalytic Activity. Cell chemical biology vol. 25,12 (2018) : 1547-1553.e12.