SB-747651A (dihydrochloride)

SB-747651A dihydrochloride is an ATP-competitive mitogen- and stress-activated kinase 1 (MSK1) inhibitor with an IC50 of 11 nM. SB-747651A dihydrochloride also inhibits PRK2, RSK1, p70S6K and ROCK-II. SB-747651A dihydrochloride can be used for inflammation research[1].

Product Specifications

CAS Number

[1781882-72-1]

UNSPSC

12352005

Target

P38 MAPK; Ribosomal S6 Kinase (RSK)

Type

Reference compound

Related Pathways

MAPK/ERK Pathway

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/sb-747651a-dihydrochloride.html

Concentration

10mM

Purity

99.14

Solubility

H2O : 50 mg/mL (ultrasonic)

Smiles

NC1=NON=C1C(N2CC)=NC3=C2C(CNC4CCNCC4)=CN=C3.[H]Cl.[H]Cl

Molecular Formula

C16H24Cl2N8O

Molecular Weight

415.32

References & Citations

[1]Shaista Naqvi, et al. Characterization of the cellular action of the MSK inhibitor SB-747651A. Biochem J. 2012 Jan 1;441 (1) :347-57.|[2]Feiner B, et al. Risperidone effects on heterochromatin: the role of kinase signaling. Clin Exp Immunol. 2019;196 (1) :67-75.|[3]Hossain M, et al. The Specific Mitogen- and Stress-Activated Protein Kinase MSK1 Inhibitor SB-747651A Modulates Chemokine-Induced Neutrophil Recruitment. Int J Mol Sci. 2017;18 (10) :2163. Published 2017 Oct 17.