H-0106 (dihydrochloride)
H-0106 dihydrochloride is a ROCK inhibitor with potent intraocular pressure (IOP) -lowering activity. H-0106 dihydrochloride can effectively inhibit ROCK enzyme. H-0106 dihydrochloride demonstrated significant IOP-lowering effects in monkey eyes. Studies with H-0106 dihydrochloride suggest that there may not be a direct relationship between ROCK inhibition and IOP reduction[1].
Product Specifications
CAS Number
[1011465-90-9]
UNSPSC
12352005
Target
Endogenous Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/h-0106-dihydrochloride.html
Smiles
O=S(C1=CC=CC2=C1C(Cl)=CN=C2)(N3[C@H](CNCCCC3)C)=O.[H]Cl.[H]Cl
Molecular Formula
C16H22Cl3N3O2S
Molecular Weight
426.79
References & Citations
[1]IOP-lowering effect of isoquinoline-5-sulfonamide compounds in ocular normotensive monkeys
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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