iFluor™ 647 Conjugated MUC1 Mouse Monoclonal Antibody [PSH0-48]
This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants.
Product Specifications
Product Name Alternative
Abbreviation
MUC1
Swiss Prot
P15941 Human
Cellular Locus
Apical cell membrane. Secreted. Nucleus, Cell membrane, Cytoplasm.
Host
Mouse
Species Reactivity
Human
Immunogen
Synthetic peptide of core peptide domain of human MUC1.
Isotype
IgG2a
Clone
PSH0-48
Conjugation
iFluor™ 647
Type
Mouse monoclonal Antibody
Applications
FC
Positive Control
MCF7, SK-Br-3.
Concentration
1 mg/mL
Dilution
FC: 1:500-1:1,000
Purity
Protein A affinity purified.
Form
Liquid
Buffer
Preservative: 0.02% Sodium azide Constituents: 30% Glycerol, 1% BSA, 68.98% PBS
Molecular Weight
Predicted band size: 122 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No
CAS Number
9007-83-4
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
