GSK343

GSK343, a chemical probe, is a highly potent and selective EZH2 inhibitor with an IC50 of 4 nM.

Product Specifications

CAS Number

[1346704-33-3]

UNSPSC

12352005

Hazard Statement

H302

Target

Autophagy; Histone Methyltransferase

Type

Reference compound

Related Pathways

Autophagy; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/GSK343.html

Purity

99.46

Solubility

DMSO : 15.62 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(C1=CC(C2=CC(N3CCN(C)CC3)=NC=C2)=CC4=C1C=NN4C(C)C)NCC5=C(CCC)C=C(C)NC5=O

Molecular Formula

C31H39N7O2

Molecular Weight

541.69

Precautions

H302

References & Citations

[1]Sharad K, et al. Identification of Potent, Selective, Cell-Active Inhibitors of the Histone Lysine Methyltransferase EZH2. ACS Med Chem Lett. 2012 Oct 19;3 (12) :1091-6.|[2]Ding M, et al. The polycomb group protein enhancer of zeste 2 is a novel therapeutic target for cervical cancer. Clin Exp Pharmacol Physiol. 2015 May;42 (5) :458-64.