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Mequitazine-d8 (hydrobromide)

Mequitazine-d8 hydrobromide is deuterated labeled Mequitazine. Mequitazine is a potent, and long-acting histamine H1 antagonist.

Product Specifications

Product Name Alternative

LM-209-d8 (hydrobromide)

UNSPSC

12352005

Target

Histamine Receptor; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling; Others

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology; Inflammation/Immunology

Solubility

10 mM in DMSO

Smiles

[2H]C1=C([2H])C([2H])=C2SC3=C(C([2H])=C([2H])C([2H])=C3[2H])N(CC4CN5CCC4CC5)C2=C1[2H].Br

Molecular Formula

C20H15D8BrN2S

Molecular Weight

411.43

References & Citations

[1]Gonnot V, et al. Expedient synthesis of mequitazine an antihistaminic drug by palladium catalyzed allylic alkylation of sodium phenothiazinate. Chem Pharm Bull (Tokyo) . 2009 Nov;57 (11) :1300-2.|[2]El-Nakeeb MA, et a. In vitro antibacterial activity of some antihistaminics belonging to different groups against multi-drug resistant clinical isolates. Braz J Microbiol. 2011 Jul;42 (3) :980-91.|[3]Martinez-Mir I, et al. Antihistaminic and anticholinergic activities of mequitazine in comparison with clemizole. J Pharm Pharmacol. 1988 Sep;40 (9) :655-6.|[4]Satake N, et al. Possible mechanisms of vasoinhibitory effects of mequitazine, an antiallergic agent, on the contractions of isolated rat aorta induced by K+, phenylephrine, 5-hydroxytryptamine, and Ca2+. J Cardiovasc Pharmacol. 1994 Apr;23 (4) :669-73.|[5]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.

Shipping Conditions

Room temperature

Scientific Category

Isotope-Labeled Compounds

Clinical Information

No Development Reported

Frequently Asked Questions

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