What is the catalog number for SPI-001?

The catalog number for SPI-001 is HY-164537.

SPI-001 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures SPI-001?

SPI-001 is manufactured by QuantiMol.

What is the estimated delivery time for SPI-001?

Estimated delivery time for SPI-001 is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for SPI-001?

The safety data sheet for SPI-001 is available here: http://file.medchemexpress.com/batch_PDF/HY-164537/.

SPI-001

Product Specifications

CAS Number

1220996-46-2

UNSPSC Description

SPI-001 is a PPM1D-specific inhibitor (IC50=0.48 μM) with anticancer activity. SPI-001 inhibits PPM1D phosphatase activity and increases p53 phosphorylation in PPM1D-overexpressing human breast cancer cells. In addition, SPI-001 inhibits cell proliferation by inducing apoptosis[1].

Target Antigen

Apoptosis; MDM-2/p53; Phosphatase

Type

Reference compound

Related Pathways

Apoptosis;Metabolic Enzyme/Protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/spi-001.html

Smiles

C[C@H]1C[C@@H](O[Si](CC)(CC)CC)[C@]2([H])[C@@]([C@@](C[C@@H](O)C[C@]3(CO)C)(C)[C@]3([H])[C@@H](O[Si](C)(C(C)(C)C)C)C2)([H])C1

Molecular Weight

540.97

References & Citations

[1]Yagi, et al. "A small molecule inhibitor of p53-inducible protein phosphatase PPM1D." Bioorganic & medicinal chemistry letters 22.1 (2012): 729-732.