SPI-001
Product Specifications
CAS Number
1220996-46-2
UNSPSC Description
SPI-001 is a PPM1D-specific inhibitor (IC50=0.48 μM) with anticancer activity. SPI-001 inhibits PPM1D phosphatase activity and increases p53 phosphorylation in PPM1D-overexpressing human breast cancer cells. In addition, SPI-001 inhibits cell proliferation by inducing apoptosis[1].
Target Antigen
Apoptosis; MDM-2/p53; Phosphatase
Type
Reference compound
Related Pathways
Apoptosis;Metabolic Enzyme/Protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/spi-001.html
Smiles
C[C@H]1C[C@@H](O[Si](CC)(CC)CC)[C@]2([H])[C@@]([C@@](C[C@@H](O)C[C@]3(CO)C)(C)[C@]3([H])[C@@H](O[Si](C)(C(C)(C)C)C)C2)([H])C1
Molecular Weight
540.97
References & Citations
[1]Yagi, et al. "A small molecule inhibitor of p53-inducible protein phosphatase PPM1D." Bioorganic & medicinal chemistry letters 22.1 (2012): 729-732.
Shipping Conditions
Room temperature
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS1219759-01 0.02 mg (E-Coli)
Recombinant Salmonella typhimurium Glucose-specific phosphotransferase enzyme IIA component (crr)
Sign In for Pricing
View Details MBS1219759-02 0.1 mg (E-Coli)
Recombinant Salmonella typhimurium Glucose-specific phosphotransferase enzyme IIA component (crr)
Sign In for Pricing
View Details MBS1219759-03 0.02 mg (Yeast)
Recombinant Salmonella typhimurium Glucose-specific phosphotransferase enzyme IIA component (crr)
Sign In for Pricing
View Details MBS1219759-04 0.1 mg (Yeast)
Recombinant Salmonella typhimurium Glucose-specific phosphotransferase enzyme IIA component (crr)
Sign In for Pricing
View Details MBS1219759-05 0.02 mg (Baculovirus)
Recombinant Salmonella typhimurium Glucose-specific phosphotransferase enzyme IIA component (crr)
Sign In for Pricing
View Details MBS1219759-06 0.02 mg (Mammalian-Cell)
Recombinant Salmonella typhimurium Glucose-specific phosphotransferase enzyme IIA component (crr)
Sign In for Pricing
View Details