MOG (35-55) (acetate)

MOG (35-55) (Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat) acetate is a minor component of CNS myelin. MOG (35-55) (acetate) has encephalitogenic activity and induces T cell proliferative. MOG (35-55) (acetate) induces Th1 cytokine response as well as relatively high levels of IgG antibodies. MOG (35-55) (acetate) produces a relapsing-remitting neurological disease with extensive plaque-like demyelination. MOG (35-55) (Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat) acetate can be used for experimental autoimmune encephalomyelitis (EAE) modeling[1][2][3].

Product Specifications

Product Name Alternative

Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat (acetate)

UNSPSC

12352209

Target

Others

Type

Peptides

Related Pathways

Others

Applications

COVID-19-immunoregulation

Field of Research

Neurological Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/myelin-oligodendrocyte-glycoprotein-peptide-35-55-mouse-rat-acetate.html

Purity

99.86

Solubility

H2O : 100 mg/mL (ultrasonic)

Smiles

OC(C(F)(F)F)=O.O=C([C@@H](N)CCSC)N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N1[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(O)=O)CCCCN)=O)=O)CC(N)=O)=O)CCCNC(N)=N)=O)CC2=CC=C(O)C=C2)=O)CC(C)C)=O)CC3=CNC=N3)=O)C(C)C)=O)C(C)C)=O)CCCNC(N)=N)=O)CO)=O)CC4=CC=CC=C4)=O)CCC1)=O)CO)=O)CCCNC(N)=N)=O)CC5=CC=C(O)C=C5)=O)CC6=CNC7=CC=CC=C67)=O)=O)C(C)C)=O)CCC(O)=O

Molecular Formula

C120H181N35O31S

Molecular Weight

2642.00

References & Citations

[1]Rich C, et, al. Myelin oligodendrocyte glycoprotein-35-55 peptide induces severe chronic experimental autoimmune encephalomyelitis in HLA-DR2-transgenic mice. Eur J Immunol. 2004 May;34 (5) :1251-61.|[2]Slavin A, et, al. Induction of a multiple sclerosis-like disease in mice with an immunodominant epitope of myelin oligodendrocyte glycoprotein. Autoimmunity. 1998;28 (2) :109-20.|[3]Giralt M, et, al. Active Induction of Experimental Autoimmune Encephalomyelitis (EAE) with MOG35-55 in the Mouse. Methods Mol Biol. 2018;1791:227-232.