QX-314 (chloride)
QX-314 chloride is a membrane-impermeable permanently charged sodium channel blocker[1].
Product Specifications
CAS Number
5369-03-9
UNSPSC
12352005
Target
Sodium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/qx-314-chloride.html
Concentration
10mM
Purity
99.96
Solubility
DMSO : 12.5 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 50 mg/mL (ultrasonic)
Smiles
O=C(NC1=C(C)C=CC=C1C)C[N+](CC)(CC)CC.[Cl-]
Molecular Formula
C16H27ClN2O
Molecular Weight
298.85
References & Citations
[1]Rivera-Acevedo RE, et al. The quaternary lidocaine derivative, QX-314, exerts biphasic effects on transient receptor potential vanilloid subtype 1 channels in vitro. Anesthesiology. 2011 Jun;114 (6) :1425-34.|[2]Talbot MJ, et al. Intracellular QX-314 inhibits calcium currents in hippocampal CA1 pyramidal neurons. J Neurophysiol. 1996 Sep;76 (3) :2120-4.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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