Yangambin

Yangambin, a furofuran lignan, is already isolated from plants such as member of the Annonaceae family, including species of the genus Rollinia: R. pickeli, R. exalbidaand R. mucosa, as well from the Magnolia biondii. Yangambin, a selective PAF receptor antagonist, inhibits Ca2+ influx through voltage-gated Ca2+ channels, leading to the reduction in [Ca2+]i in vascular smooth muscle cells and consequent peripheral vasodilation[1]. Yangambin exhibits the antiallergic activity against β-hexosaminidase release with an IC50 of 33.8 μM and for anti-inflammatory activity with an IC50 of 37.4 μM[2].

Product Specifications

CAS Number

[13060-14-5]

UNSPSC

12352005

Target

Calcium Channel

Type

Natural Products

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Infection; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/yangambin.html

Purity

98.27

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

COC1=C(OC)C(OC)=CC([C@H]2OC[C@]3([H])[C@@H](C4=CC(OC)=C(OC)C(OC)=C4)OC[C@@]32[H])=C1

Molecular Formula

C24H30O8

Molecular Weight

446.49

References & Citations

[1]Araújo IG, et al. Calcium influx inhibition is involved in the hypotensive and vasorelaxant effects induced by yangambin. Molecules. 2014 May 23;19 (5) :6863-76.|[2]Jindaporn Puripattanavong, et al. Anti-allergic and anti-inflammatory compounds from Aglaia andamanica leaves. Songklanakarin J. Sci. Technol. 2015,37 (1), 37-41.