AA43279
AA43279 is an in gamma-aminobutyric acid (GABA) fast-firing interneurons located activator for Nav1.1 channel (SCN1A) with an EC50 of 9.5 μM. AA43279 enhances specific neuronal firing activity in vitro, and exhibits anticonvulsant activity in rat MEST model[1].
Product Specifications
CAS Number
354812-16-1
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Sodium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/aa43279.html
Purity
99.80
Solubility
DMSO : 6.67 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=C(N)C=C(C2=CC=C(OC)C=C2)S1)N
Molecular Formula
C12H12N2O2S
Molecular Weight
248.31
Precautions
H302, H315, H319, H335
References & Citations
[1]Frederiksen K, et al., A small molecule activator of Nav 1.1 channels increases fast-spiking interneuron excitability and GABAergic transmission in vitro and has anti-convulsive effects in vivo. Eur J Neurosci. 2017 Aug;46 (3) :1887-1896.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Nav1.1; Nav1.2; Nav1.5; Nav1.6
Available Sizes
Frequently Asked Questions
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