CLK8

CLK8 is a potent and specific CLOCK inhibitor that can disrupt the interaction between CLOCK and BMAL1 and interfere with nuclear translocation of CLOCK. CLK8 can be used for the research of disorders associated with dampened circadian rhythms[1].

Product Specifications

CAS Number

[898920-65-5]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Cryptochrome

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/clk8.html

Purity

98.06

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(COC1=C(C(C2=CC=CC=C2)=CC(O3)=O)C3=C(CCC(C)(C)O4)C4=C1)NC5=C(C(N)=O)C=CC=C5

Molecular Formula

C29H26N2O6

Molecular Weight

498.53

Precautions

H315, H319, H335

References & Citations

[1]Doruk YU, et, al. A CLOCK-binding small molecule disrupts the interaction between CLOCK and BMAL1 and enhances circadian rhythm amplitude. J Biol Chem. 2020 Mar 13;295 (11) :3518-3531.