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Pholedrine (hydrochloride)

Pholedrine hydrochloride, the main metabolite of methamphetamine, is an indirectly acting sympathomimetic amine. Pholedrine hydrochloride is a cardiovascular agent exerting hypertensive and adrenergic effects. Pholedrine hydrochloride can produce mydriatic response and allow localization of the site of the interruption in the oculosympathetic pathway. Pholedrine hydrochloride can be used as a topical eye drop and a diagnostic agent for use in Horner's syndrome[1][2][3].

Product Specifications

CAS Number

877-86-1

UNSPSC

12352005

Target

Drug Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/pholedrine-hydrochloride.html

Purity

99.63

Solubility

10 mM in DMSO

Smiles

OC1=CC=C(CC(C)NC)C=C1.Cl

Molecular Formula

C10H16ClNO

Molecular Weight

201.69

References & Citations

[1]Peinhardt GP. High-performance liquid chromatographic determination of pholedrine in human serum using ion-pair extraction and amperometric detection. J Chromatogr B Biomed Sci Appl. 1999 Apr 16;726 (1-2) :309-12.|[2]A T Bates, et al. Pholedrine: a substitute for hydroxyamphetamine as a diagnostic eyedrop test in Horner's syndrome. J Neurol Neurosurg Psychiatry. 1995 Feb;58 (2) :215-7.|[3]Richard Bade, et al. Pholedrine is a marker of direct disposal of methamphetamine. Sci Total Environ. 2021 Aug 15;782:146839.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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