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Waglerin-1

Waglerin-1, a 22-amino acid peptide, is a competitive antagonist of the muscle nicotinic receptor (nAChR) [1].

Product Specifications

CAS Number

145038-84-2

UNSPSC

12352209

Target

GABA Receptor; nAChR

Type

Peptides

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/waglerin-1.html

Purity

98.71

Solubility

DMSO : 3.33 mg/mL (ultrasonic)

Smiles

O=C(CN)NCC(N[C@H](C(N1[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N2[C@H](C(N[C@H](C(N[C@H](C(N3[C@H](C(N4[C@H]5CCC4)=O)CCC3)=O)CC6=CNC=N6)=O)CSSC[C@H](NC5=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N7[C@H](C(N[C@H](C(N8[C@H](C(N[C@H](C(N9[C@H](C(N[C@H](C(O)=O)CCCNC(N)=N)=O)CCC9)=O)CCCCN)=O)CCC8)=O)CCCNC(N)=N)=O)CCC7)=O)[C@H](CC)C)=O)CC%10=CC=C(O)C=C%10)=O)CC%11=CNC=N%11)=O)=O)CCC2)=O)CCCNC(N)=N)=O)CC(C)C)=O)CC(O)=O)=O)CCC1)=O)CCCCN)=O

Molecular Formula

C112H175N37O26S2

Molecular Weight

2519.95

References & Citations

[1]Brian E Molles, et al. Identification of Residues at the α and ε Subunit Interfaces Mediating Species Selectivity of Waglerin-1 for Nicotinic Acetylcholine Receptors. J Biol Chem. 2002 Feb 15;277 (7) :5433-40.|[2]J H Ye, et al. Waglerin-1 inhibits GABAA current of neurons in the nucleus accumbens of neonatal rats. Brain Res. 1999 Aug 7;837 (1-2) :29-37.

Shipping Conditions

Blue Ice

Storage Conditions

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

Scientific Category

Peptides

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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