IM176OUT05

IM176OUT05 (2-Me-Phen hydrochloride), a biguanide, is a mitochondrial OXPHOS inhibitor. IM176OUT0 inhibits mitochondrial electron transport chain (ETC) activity with an IC50 of 3.2 μM. IM176OUT05 activates stem cell metabolism, promotes hair regrowth and increases stemness induction and maintenance during the pluripotent stem cell generation process[1].

Product Specifications

CAS Number

[1643659-96-4]

Product Name Alternative

2-Me-Phen (hydrochloride) ; 2-Me-Phenformin (hydrochloride)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Mitochondrial Metabolism; Oxidative Phosphorylation

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/im176out05.html

Purity

99.43

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

NC(NC(NCCC1=CC=CC=C1C)=N)=N.Cl

Molecular Formula

C11H18ClN5

Molecular Weight

255.75

Precautions

H302, H315, H319, H335

References & Citations

[1]Son MJ, et al. A novel and safe small molecule enhances hair follicle regeneration by facilitating metabolic reprogramming. Exp Mol Med. 2018 Dec 6;50 (12) :1-15.