Callicarboric acid A
Product Specifications
UNSPSC Description
NLRP3-IN-27 (compound 1) is an inhibitor of NLRP3 with an IC50 value of 0.74 μM. NLRP3 reduces inflammasome-induced pyroptosis in J774A.1 cells. NLRP3-IN-27 can be isolated from Callicarpa arborea Rox[1].
Target Antigen
NOD-like Receptor (NLR)
Type
Natural Products
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/callicarboric-acid-a.html
Solubility
10 mM in DMSO
Smiles
O=C1C=C[C@](CCCCCCCC(OC)=O)([H])[C@@]1([H])CC(/C=C/C)=O
Molecular Weight
320.42
References & Citations
[1]Muhammad Aurang Zeb, et al. Two New Prostaglandin-Like Compounds from Callicarpa arborea Roxb and Their NLRP3 Inflammasome Activation Inhibitory Activity. Chem Biodivers. 2023, 20, 12.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-N12482/Callicarboric-acid-A-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-N12482/
Clinical Information
No Development Reported
Curated Selection
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