Callicarboric acid A

NLRP3-IN-27 (compound 1) is an inhibitor of NLRP3 with an IC50 value of 0.74 μM. NLRP3 reduces inflammasome-induced pyroptosis in J774A.1 cells. NLRP3-IN-27 can be isolated from Callicarpa arborea Rox[1].

Product Specifications

UNSPSC

12352211

Target

NOD-like Receptor (NLR)

Type

Natural Products

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/callicarboric-acid-a.html

Solubility

10 mM in DMSO

Smiles

O=C1C=C[C@](CCCCCCCC(OC)=O)([H])[C@@]1([H])CC(/C=C/C)=O

Molecular Formula

C19H28O4

Molecular Weight

320.42

References & Citations

[1]Muhammad Aurang Zeb, et al. Two New Prostaglandin-Like Compounds from Callicarpa arborea Roxb and Their NLRP3 Inflammasome Activation Inhibitory Activity. Chem Biodivers. 2023, 20, 12.