Callicarboric acid A
NLRP3-IN-27 (compound 1) is an inhibitor of NLRP3 with an IC50 value of 0.74 μM. NLRP3 reduces inflammasome-induced pyroptosis in J774A.1 cells. NLRP3-IN-27 can be isolated from Callicarpa arborea Rox[1].
Product Specifications
UNSPSC
12352211
Target
NOD-like Receptor (NLR)
Type
Natural Products
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/callicarboric-acid-a.html
Solubility
10 mM in DMSO
Smiles
O=C1C=C[C@](CCCCCCCC(OC)=O)([H])[C@@]1([H])CC(/C=C/C)=O
Molecular Formula
C19H28O4
Molecular Weight
320.42
References & Citations
[1]Muhammad Aurang Zeb, et al. Two New Prostaglandin-Like Compounds from Callicarpa arborea Roxb and Their NLRP3 Inflammasome Activation Inhibitory Activity. Chem Biodivers. 2023, 20, 12.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Curated Selection
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