T.cruzi-IN-1

T.cruzi-IN-1 is a potent Trypanosoma cruzi inhibitor with an IC50 of 8 nM. T.cruzi-IN-1, a 4-trifluoromethyl substituted analog, has the potential for both the acute and chronic stages of Chagas disease[1].

Product Specifications

CAS Number

[1350920-22-7]

UNSPSC

12352005

Hazard Statement

H302, H315, H320, H335

Target

Parasite

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/t-cruzi-in-1.html

Concentration

10mM

Purity

99.11

Solubility

DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(C1CN(CC2=CC=C(C(F)(F)F)C=C2)CCC1)N(C)CC3=CC=CC=C3

Molecular Formula

C22H25F3N2O

Molecular Weight

390.44

Precautions

H302, H315, H320, H335

References & Citations

[1]Germain AR, et al. Identification of small-molecule inhibitors of Trypansoma cruzi replication. Bioorg Med Chem Lett. 2011 Dec 1;21 (23) :7197-200.