Sublancin

Sublancin is an antimicrobial peptide, which inhibits DNA replication, transcription and translation, without affecting membrane integrity. Sublancin suppresses glucose uptake for the competition of phosphotransferase system (PTS) . Sublancin inhibits B. subtilis strain 168 ΔSPβ with MIC of 0.312 μM[1][2].

Product Specifications

CAS Number

[207410-26-2]

UNSPSC

12352209

Target

Bacterial

Type

Peptides

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/sublancin.html

Solubility

10 mM in DMSO

Smiles

O[C@H]1C(SC[C@@H](C(NCC(NCC(NCC(N[C@H](C(N[C@H](C(N[C@H]2C)=O)C(C)C)=O)C)=O)=O)=O)=O)NC(CNC([C@H]([C@H](CC)C)NC([C@H]([C@@H](C)O)NC(CNC(CNC([C@H](CO)NC([C@H](C)NC([C@H](CSSC[C@H](NC2=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]3CC4=CC=CC=C4)=O)CCC(N)=O)=O)CCCNC(N)=N)=O)CC5=CC=C(O)C=C5)=O)CC(N)=O)=O)CCC(N)=O)=O)NC([C@H](CCC(N)=O)NC([C@H](CC(C)C)NC([C@H](CC6=CNC7=CC=CC=C67)NC([C@H](CC(C)C)NC([C@H](C)NC([C@H](C)NC([C@H](CSSC[C@H](NC3=O)C(N[C@H](C(O)=O)CCCNC(N)=N)=O)NC([C@H](CCC(N)=O)NC([C@H](C)NC([C@H](CCCCN)NC(CNC([C@H](CC(C)C)NC(CN)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)O[C@H](CO)[C@@H](O)[C@@H]1O

Molecular Formula

C162H254N50O51S5

Molecular Weight

3878.38

References & Citations

[1]Wang S, et al., Use of the Antimicrobial Peptide Sublancin with Combined Antibacterial and Immunomodulatory Activities To Protect against Methicillin-Resistant Staphylococcus aureus Infection in Mice. J Agric Food Chem. 2017 Oct 4;65 (39) :8595-8605.|[2]Wu C, et al., Investigations into the Mechanism of Action of Sublancin. ACS Infect Dis. 2019 Mar 8;5 (3) :454-459.