Izorlisib

Izorlisib (CH5132799) is a selective class I PI3K inhibitor. Izorlisib inhibits class I PI3Ks, particularly PI3Kα, with an IC50 of 14 nM.

Product Specifications

CAS Number

[1007207-67-1]

Product Name Alternative

CH5132799

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

PI3K

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/izorlisib.html

Purity

99.01

Solubility

DMSO : 4.55 mg/mL (ultrasonic)

Smiles

NC1=NC=C(C2=C3C(N(S(=O)(C)=O)CC3)=NC(N4CCOCC4)=N2)C=N1

Molecular Formula

C15H19N7O3S

Molecular Weight

377.42

Precautions

H302, H315, H319, H335

References & Citations

[1]Tanaka H, et al. The selective class I PI3K inhibitor CH5132799 targets human cancers harboring oncogenic PIK3CA mutations. Clin Cancer Res, 2011, 17 (10), 3272-3281.|[2]Ohwada J, et al. Discovery and biological activity of a novel class I PI3K inhibitor, CH5132799. Bioorg Med Chem Leff, 2011, 21 (6), 1767-1772.