Bufalin (Standard)
Bufalin (Standard) is the analytical standard of Bufalin. This product is intended for research and analytical applications. Bufalin is an active component isolated from Chan Su, acts as a potent Na+/K+-ATPase inhibitor, binds to the subunit α1, α2 and α3, with Kd of 42.5, 45 and 40 nM, respectively[1][2]. Anti-cancer activity[2].
Product Specifications
CAS Number
465-21-4
UNSPSC
12352005
Target
Na+/K+ ATPase; Reference Standards
Type
Reference Standards
Related Pathways
Membrane Transporter/Ion Channel; Others
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bufalin-standard.html
Smiles
O[C@]([C@@](CC[C@@]1([H])[C@@]2(CC[C@H](O)C1)C)([H])[C@]2([H])CC3)(CC[C@@H]4C(C=C5)=COC5=O)[C@]34C
Molecular Formula
C24H34O4
Molecular Weight
386.52
References & Citations
[1]Katz A, et al. Selectivity of digitalis glycosides for isoforms of human Na, K-ATPase. J Biol Chem. 2010 Jun 18;285 (25) :19582-92.|[2]Wu SH, et al. Bufalin induces apoptosis in vitro and has Antitumor activity against human lung cancer xenografts in vivo. Environ Toxicol. 2017 Apr;32 (4) :1305-1317.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Frequently Asked Questions
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