Fiduxosin (hydrochloride)

Fiduxosin hydrochloride (ABT 980) is a potent α1-adrenoceptor antagonist, with Ki of 0.160 nM, 24.9 nM, and 0.920 nM for α1a-, α1b-, and α1d-adrenoceptors, respectively[1].

Product Specifications

CAS Number

[208992-74-9]

Product Name Alternative

ABT 980

UNSPSC

12352005

Hazard Statement

H315-H319-H335

Target

Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/fiduxosin-hydrochloride.html

Smiles

O=C1C2=C(NC(N1CCCCN3C[C@]4([H])[C@](COC5=CC=CC(OC)=C54)([H])C3)=O)C6=NC(C7=CC=CC=C7)=CN=C6S2.Cl

Molecular Formula

C30H30ClN5O4S

Molecular Weight

592.11

Precautions

P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362+P364-P403+P233-P405-P501

References & Citations

[1]Hancock AA, et al. Preclinical pharmacology of fiduxosin, a novel alpha (1) -adrenoceptor antagonist with uroselective properties. J Pharmacol Exp Ther. 2002 Feb;300 (2) :478-86.|[2]Brune ME, et al. Effect of fiduxosin, an antagonist selective for alpha (1A) - and alpha (1D) -adrenoceptors, on intraurethral and arterial pressure responses in conscious dogs. J Pharmacol Exp Ther. 2002 Feb;300 (2) :487-94.