Fiduxosin (hydrochloride)
Fiduxosin hydrochloride (ABT 980) is a potent α1-adrenoceptor antagonist, with Ki of 0.160 nM, 24.9 nM, and 0.920 nM for α1a-, α1b-, and α1d-adrenoceptors, respectively[1].
Product Specifications
CAS Number
208992-74-9
Product Name Alternative
ABT 980
UNSPSC
12352005
Hazard Statement
H315-H319-H335
Target
Adrenergic Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/fiduxosin-hydrochloride.html
Smiles
O=C1C2=C(NC(N1CCCCN3C[C@]4([H])[C@](COC5=CC=CC(OC)=C54)([H])C3)=O)C6=NC(C7=CC=CC=C7)=CN=C6S2.Cl
Molecular Formula
C30H30ClN5O4S
Molecular Weight
592.11
Precautions
P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362+P364-P403+P233-P405-P501
References & Citations
[1]Hancock AA, et al. Preclinical pharmacology of fiduxosin, a novel alpha (1) -adrenoceptor antagonist with uroselective properties. J Pharmacol Exp Ther. 2002 Feb;300 (2) :478-86.|[2]Brune ME, et al. Effect of fiduxosin, an antagonist selective for alpha (1A) - and alpha (1D) -adrenoceptors, on intraurethral and arterial pressure responses in conscious dogs. J Pharmacol Exp Ther. 2002 Feb;300 (2) :487-94.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
α adrenergic receptor
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