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NH2-UAMC1110 (TFA)

NH2-UAMC1110 TFA is a UAMC1110 derivative that can be used in the synthesis of FAPI-QS. UAMC1110 is a fibroblast activation protein (FAP) inhibitor. FAPI-QS is a chelating agent that can be used to synthesize high tumor selectivity and high dose radiotracers for the diagnosis and treatment of tumors[1][2].

Product Specifications

CAS Number

2990021-73-1

UNSPSC

12352005

Target

Drug Derivative; Drug Intermediate; FAP

Type

Reference compound

Related Pathways

Immunology/Inflammation; Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/nh2-uamc1110-tfa.html

Purity

99.84

Solubility

H2O : 250 mg/mL (ultrasonic)

Smiles

O=C(N1[C@@H](CC(F)(C1)F)C#N)CNC(C2=CC=NC3=C2C=C(OCCCCN)C=C3)=O.O=C(O)C(F)(F)F

Molecular Formula

C23H24F5N5O5

Molecular Weight

545.46

References & Citations

[1]Euy Sung Moon, et al. Targeting fibroblast activation protein (FAP) : next generation PET radiotracers using squaramide coupled bifunctional DOTA and DATA5m chelators. EJNMMI Radiopharm Chem. 2020 Jul 29;5 (1) :19. |[2]Kristina Hoot Young, et al. Preclinical combination of radiation and fibroblast activation protein inhibition in pancreatic cancer. Journal of Clinical Oncology. 2016, 34 (15) .

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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