S107
S107 is an orally available, blood brain barrier-permeable compound, which stabilizes RyR2 channels by enhancing the binding of calstabin 2 to the mutant Ryr2-R2474S channel. S107 inhibits Ca2+ leakage from the sarcoplasmic reticulum (SR) and prevents cardiac arrhythmias and raises the seizure threshold[1][2].
Product Specifications
CAS Number
[927871-76-9]
UNSPSC
12352005
Hazard Statement
H302
Target
Calcium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/S107.html
Concentration
10mM
Purity
99.77
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
COC1=CC=C2C(CN(C)CCS2)=C1
Molecular Formula
C11H15NOS
Molecular Weight
209.31
Precautions
H302
References & Citations
2+
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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