Meldonium

Meldonium (MET-88) functions as a cardioprotective agent by cpmpetetively inhibiting γ-butyrobetaine hydroxylase (BBOX) and carnitine/organic cation transporter type 2 (OCTN2) . Meldonium exhibits IC50 values of 34-62 μM for human recombinant BBOX and an EC50 of 21 μM for human OCTN2. Meldonium is a fatty acid oxidation inhibitor[1][2].

Product Specifications

CAS Number

[76144-81-5]

Product Name Alternative

MET-88; Quaterin

UNSPSC

12352211

Hazard Statement

H315, H319, H335

Target

Mitochondrial Metabolism

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Metabolic Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/meldonium.html

Purity

99.89

Solubility

H2O : 50 mg/mL (ultrasonic)

Smiles

C[N+](C)(C)NCCC([O-])=O

Molecular Formula

C6H14N2O2

Molecular Weight

146.19

Precautions

H315, H319, H335

References & Citations

[1]Dambrova M, et al. Pharmacological effects of meldonium: Biochemical mechanisms and biomarkers of cardiometabolic activity. Pharmacol Res. 2016 Nov;113 (Pt B) :771-780.|[2]Jolanta Pupure, et al. Neuroprotective properties of mildronate, a mitochondria-targeted small molecule. Neurosci Lett. 2010 Feb 12;470 (2) :100-5.|[3]Daohui Wang, et al. Meldonium Ameliorates Hypoxia-Induced Lung Injury and Oxidative Stress by Regulating Platelet-Type Phosphofructokinase-Mediated Glycolysis. Front Pharmacol. 2022 Apr 5:13:863451.