RO7185876
RO7185876 is a potent and selective gamma secretase modulator as a potential research for Alzheimer's disease.
Product Specifications
CAS Number
[2226038-71-5]
UNSPSC
12352005
Target
γ-secretase
Type
Reference compound
Related Pathways
Neuronal Signaling; Stem Cell/Wnt
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ro7185876.html
Purity
99.9
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
FC(C(F)=C(C=C1)F)=C1[C@@]2([H])C3=NC(N[C@H]4[C@@H]5CN(C6=NC=NC(C)=C6)C[C@H]4CC5)=NN3CCCC2
Molecular Formula
C25H28F3N7
Molecular Weight
483.53
References & Citations
[1]Ratni H, et al. Discovery of RO7185876, a Highly Potent γ-Secretase Modulator (GSM) as a Potential Treatment for Alzheimer's Disease. ACS Med Chem Lett. 2020 Apr 27;11 (6) :1257-1268.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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