LP17
LP17 (LQVTDSGLYRCVIYHPP) is a BBB-penetrable triggering receptor expressed on myeloid cells (TREM-1) inhibitory peptide. LP17 substantially alleviates ischemia-induced infarction and neuronal injury. LP17 can get access into brain and block TREM-1[1].
Product Specifications
CAS Number
887255-16-5
Product Name Alternative
LQVTDSGLYRCVIYHPP
UNSPSC
12352209
Target
Others
Type
Peptides
Related Pathways
Others
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/lqvtdsglyrcviyhpp.html
Purity
99.78
Solubility
DMSO : 20 mg/mL (ultrasonic; warming; adjust pH to 7 with CH3COOH; heat to 37°C) |H2O : 35.71 mg/mL (adjust pH to 3 with CH3COOH)
Smiles
O=C(N1[C@@H](CCC1)C(O)=O)[C@H]2N(CCC2)C([C@@H](NC([C@@H](NC([C@H]([C@@H](C)CC)NC([C@H](C(C)C)NC([C@H](CS)NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@H](CC(C)C)NC(CNC([C@H](CO)NC([C@H](CC(O)=O)NC([C@H]([C@H](O)C)NC([C@H](C(C)C)NC([C@H](CCC(N)=O)NC([C@@H](N)CC(C)C)=O)=O)=O)=O)=O)=O)=O)=O)CC3=CC=C(C=C3)O)=O)=O)=O)=O)=O)CC4=CC=C(C=C4)O)=O)CC5=CN=CN5)=O
Molecular Formula
C89H137N23O25S
Molecular Weight
1961.24
References & Citations
[1]Pengfei Xu, et al. Microglial TREM-1 receptor mediates neuroinflammatory injury via interaction with SYK in experimental ischemic stroke. Cell Death Dis. 2019 Jul 19;10 (8) :555.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)
Scientific Category
Peptides
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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