Ac-RYYRWK-NH2

Ac-RYYRWK-NH2 is a potent and selective partial agonist for the nociceptin receptor (NOP), [3H]Ac-RYYRWK-NH2 binds to rat cortical membranes ORL1 with a Kd of 0.071 nM, but has no affinity for µ-, κ- or δ-opioid receptors[1].

Product Specifications

CAS Number

[200959-47-3]

UNSPSC

12352209

Target

Opioid Receptor

Type

Peptides

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ac-ryyrwk-nh2.html

Solubility

10 mM in DMSO

Smiles

O=C([R][Y][Y][R][W](N)[K])C

Molecular Formula

C49H69N15O9

Molecular Weight

1012.17

References & Citations

[1]C T Dooley, et al. Binding and in vitro activities of peptides with high affinity for the nociceptin/orphanin FQ receptor, ORL1.J Pharmacol Exp Ther. 1997 Nov;283 (2) :735-41.|[2]M Ho, et al, Characterization of the ORL (1) receptor on adrenergic nerves in the rat anococcygeus muscle. Br J Pharmacol. 2000 Sep;131 (2) :349-55.