OSU-03012

OSU-03012 (AR-12; PDK1 inhibitor AR-12) is a blood-brain permeable PDK-1 inhibitor with an IC50 of 5 μM[1][3].

Product Specifications

CAS Number

[742112-33-0]

Product Name Alternative

AR-12; PDK1 inhibitor AR-12

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Autophagy; PDK-1

Type

Reference compound

Related Pathways

Autophagy; PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/OSU-03012.html

Purity

99.05

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C(CN)NC1=CC=C(C=C1)N2N=C(C=C2C3=CC=C4C5=CC=CC=C5C=CC4=C3)C(F)(F)F

Molecular Formula

C26H19F3N4O

Molecular Weight

460.45

Precautions

H302, H315, H319, H335

References & Citations

[1]Zhu J, et al. From the cyclooxygenase-2 inhibitor celecoxib to a novel class of 3-phosphoinositide-dependent protein kinase-1 inhibitors. Cancer Res. 2004 Jun 15;64 (12) :4309-18.|[2]To K, et al. The phosphoinositide-dependent kinase-1 inhibitor 2-amino-N-[4-[5- (2-phenanthrenyl) -3- (trifluoromethyl) -1H-pyrazol-1-yl]phenyl]-acetamide (OSU-03012) prevents Y-box binding protein-1 from inducing epidermal growth factor receptor. Mol Pharmacol. 2007 Sep;72 (3) :641-52.|[3]Tina X Lee, et al.Growth Inhibitory and Anti-Tumour Activities of OSU-03012, a Novel PDK-1 Inhibitor, on Vestibular Schwannoma and Malignant Schwannoma Cells. Eur J Cancer