OSU-03012
OSU-03012 (AR-12; PDK1 inhibitor AR-12) is a blood-brain permeable PDK-1 inhibitor with an IC50 of 5 μM[1][3].
Product Specifications
CAS Number
742112-33-0
Product Name Alternative
AR-12; PDK1 inhibitor AR-12
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Autophagy; PDK-1
Type
Reference compound
Related Pathways
Autophagy; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/OSU-03012.html
Purity
99.05
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C(CN)NC1=CC=C(C=C1)N2N=C(C=C2C3=CC=C4C5=CC=CC=C5C=CC4=C3)C(F)(F)F
Molecular Formula
C26H19F3N4O
Molecular Weight
460.45
Precautions
H302, H315, H319, H335
References & Citations
[1]Zhu J, et al. From the cyclooxygenase-2 inhibitor celecoxib to a novel class of 3-phosphoinositide-dependent protein kinase-1 inhibitors. Cancer Res. 2004 Jun 15;64 (12) :4309-18.|[2]To K, et al. The phosphoinositide-dependent kinase-1 inhibitor 2-amino-N-[4-[5- (2-phenanthrenyl) -3- (trifluoromethyl) -1H-pyrazol-1-yl]phenyl]-acetamide (OSU-03012) prevents Y-box binding protein-1 from inducing epidermal growth factor receptor. Mol Pharmacol. 2007 Sep;72 (3) :641-52.|[3]Tina X Lee, et al.Growth Inhibitory and Anti-Tumour Activities of OSU-03012, a Novel PDK-1 Inhibitor, on Vestibular Schwannoma and Malignant Schwannoma Cells. Eur J Cancer
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Available Sizes
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