Ac-[Nle4, D-Phe7]-α-MSH (4-10) -NH2

Ac-[Nle4, D-Phe7]-α-MSH (4-10) -NH2 is a melanotropin, a melanocyte-stimulating hormone. Ac-[Nle4, D-Phe7]-α-MSH (4-10) -NH2 stimulates tyrosinase and exhibits thermoregulatory effect in rats model[1][2].

Product Specifications

CAS Number

[82188-67-8]

UNSPSC

12352209

Target

Tyrosinase

Type

Peptides

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ac-nle4-d-phe7-α-msh-4-10-nh2.html

Purity

99.50

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(N[C@@H](CCCC)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC1=CNC=N1)C(N[C@H](CC2=CC=CC=C2)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC3=CNC4=CC=CC=C34)C(NCC(N)=O)=O)=O)=O)=O)=O)=O)C

Molecular Formula

C47H64N14O10

Molecular Weight

985.10

References & Citations

[1]Marwan MM, et al. Stimulation of S91 melanoma tyrosinase activity by superpotent alpha-melanotropins. Mol Cell Endocrinol. 1985 Jul;41 (2-3) :171-7. |[2]Lyn H, et al. α-Melanocyte-stimulating hormone (MSH) and [Nle4, D-Phe7]-α-MSH: Effects on core temperature in rats. Pharmacology Biochemistry and Behavior. 1993;44 (3) :533-538.