DIM-C-pPhCO2Me
DIM-C-pPhCO2Me is a nuclear receptor 4A1 (NR4A1) antagonist. DIM-C-pPhCO2Me induces Apoptosis. DIM-C-pPhCO2Me decreases PAX3-FOXO1A, N-Myc, Rassf4, MyoD1, Grem1, and DAPK1 proteins. DIM-C-pPhCO2Me decreases expression of TXNDC5 and IDH1, induces markers of ER stress (CHOP, ATF4 and p-PERK) . DIM-C-pPhCO2Me inhibits renal cell carcinoma, breast cancer. DIM-C-pPhCO2Me can also be used in rhabdomyosarcoma research[1][2][3][4][5].
Product Specifications
CAS Number
151358-48-4
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; DAPK; Isocitrate Dehydrogenase (IDH) ; Nuclear Hormone Receptor 4A/NR4A; PERK
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/DIM-C-pPhCO2Me.html
Purity
99.47
Solubility
DMSO : ≥ 125 mg/mL
Smiles
COC(C1=CC=C(C(C2=CNC3=C2C=CC=C3)C4=CNC5=C4C=CC=C5)C=C1)=O
Molecular Formula
C25H20N2O2
Molecular Weight
380.44
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IDH1; Nur77/NR4A1
Available Sizes
Frequently Asked Questions
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