BTX-A51
Product Specifications
Product Name Alternative
Casein Kinase inhibitor A51
UNSPSC Description
BTX-A51 (Casein Kinase inhibitor A51) is a potent and orally active casein kinase 1α (CK1α) inhibitor. BTX-A51 induces leukemia cell apoptosis, and has potent anti-leukemic activities[1].
Target Antigen
Apoptosis; Casein Kinase; CDK
Type
Reference compound
Related Pathways
Apoptosis;Cell Cycle/DNA Damage;Stem Cell/Wnt
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/btx-a51.html
Purity
98.58
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
N[C@H]1CC[C@H](NC2=NC=C(Cl)C(C3=C(CC4CC4)N(C)N=C3)=N2)CC1
Molecular Weight
360.88
References & Citations
[1]Waleed Minzel, et al. Small Molecules Co-targeting CKIα and the Transcriptional Kinases CDK7/9 Control AML in Preclinical Models. Cell. 2018 Sep 20;175(1):171-185.e25.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-123954/BTX-A51-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-123954/BTX-A51-SDS-MedChemExpress.pdf
Clinical Information
Phase 1
CAS Number
2079068-74-7
Available Sizes
Curated Selection
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