BTX-A51

BTX-A51 (Casein Kinase inhibitor A51) is a potent and orally active casein kinase 1α (CK1α) inhibitor. BTX-A51 induces leukemia cell apoptosis, and has potent anti-leukemic activities[1].

Product Specifications

CAS Number

[2079068-74-7]

Product Name Alternative

Casein Kinase inhibitor A51

UNSPSC

12352005

Target

Apoptosis; Casein Kinase; CDK

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/btx-a51.html

Concentration

10mM

Purity

98.58

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

N[C@H]1CC[C@H](NC2=NC=C(Cl)C(C3=C(CC4CC4)N(C)N=C3)=N2)CC1

Molecular Formula

C18H25ClN6

Molecular Weight

360.88

References & Citations

[1]Waleed Minzel, et al. Small Molecules Co-targeting CKIα and the Transcriptional Kinases CDK7/9 Control AML in Preclinical Models. Cell. 2018 Sep 20;175 (1) :171-185.e25.