Litronesib
Litronesib (LY2523355) is a selective mitosis-specific kinesin Eg5 inhibitor, with antitumor activity[1].
Product Specifications
CAS Number
[910634-41-2]
Product Name Alternative
LY2523355
UNSPSC
12352005
Target
Kinesin; Mitosis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Litronesib.html
Purity
99.59
Solubility
DMSO : ≥ 50 mg/mL
Smiles
CC(C)(C)C(N1[C@@](C2=CC=CC=C2)(CNS(CCNCC)(=O)=O)SC(NC(C(C)(C)C)=O)=N1)=O
Molecular Formula
C23H37N5O4S2
Molecular Weight
511.70
References & Citations
[1]Ye XS, et al. A Novel Eg5 Inhibitor (LY2523355) Causes Mitotic Arrest and Apoptosis in Cancer Cells and Shows Potent Antitumor Activity in Xenograft Tumor Models. Mol Cancer Ther. 2015 Nov;14 (11) :2463-72.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
Kinesin-5/Eg5/KSP
Available Sizes
Curated Selection
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