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IC87201

IC87201, an inhibitor of PSD95-nNOS protein-protein interactions, suppresses NMDAR-dependent NO and cGMP formation.

Product Specifications

CAS Number

866927-10-8

UNSPSC

12352005

Hazard Statement

H315, H319

Target

IGluR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/IC87201.html

Purity

97.24

Solubility

DMSO : ≥ 100 mg/mL

Smiles

OC1=C(Cl)C=C(Cl)C=C1CNC2=CC=C3N=NNC3=C2

Molecular Formula

C13H10Cl2N4O

Molecular Weight

309.15

Precautions

H315, H319

References & Citations

[1]Bach A, et al. Biochemical investigations of the mechanism of action of small molecules ZL006 and IC87201 as potential inhibitors of the nNOS-PDZ/PSD-95-PDZ interactions. Sci Rep. 2015 Jul 16;5:12157.|[2]Smith AE, et al. Source memory in rats is impaired by an NMDA receptor antagonist but not by PSD95-nNOS protein-protein interaction inhibitors. Behav Brain Res. 2016 May 15;305:23-9.|[3]Doucet MV, et al. Small-molecule inhibitors at the PSD-95/nNOS interface protect against glutamate-induced neuronal atrophy in primary cortical neurons. Neuroscience. 2015 Aug 20;301:421-38.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

NMDA Receptor

Available Sizes

Frequently Asked Questions

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