IC87201
IC87201, an inhibitor of PSD95-nNOS protein-protein interactions, suppresses NMDAR-dependent NO and cGMP formation.
Product Specifications
CAS Number
866927-10-8
UNSPSC
12352005
Hazard Statement
H315, H319
Target
IGluR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/IC87201.html
Purity
97.24
Solubility
DMSO : ≥ 100 mg/mL
Smiles
OC1=C(Cl)C=C(Cl)C=C1CNC2=CC=C3N=NNC3=C2
Molecular Formula
C13H10Cl2N4O
Molecular Weight
309.15
Precautions
H315, H319
References & Citations
[1]Bach A, et al. Biochemical investigations of the mechanism of action of small molecules ZL006 and IC87201 as potential inhibitors of the nNOS-PDZ/PSD-95-PDZ interactions. Sci Rep. 2015 Jul 16;5:12157.|[2]Smith AE, et al. Source memory in rats is impaired by an NMDA receptor antagonist but not by PSD95-nNOS protein-protein interaction inhibitors. Behav Brain Res. 2016 May 15;305:23-9.|[3]Doucet MV, et al. Small-molecule inhibitors at the PSD-95/nNOS interface protect against glutamate-induced neuronal atrophy in primary cortical neurons. Neuroscience. 2015 Aug 20;301:421-38.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NMDA Receptor
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
AM5078 2 OD, 4 OD, 50 OD
MIRacle™ rno-miR-363-3p miRNA Agomir/Antagomir
Sign In for Pricing
View Details