Methyl p-coumarate

Methyl p-coumarate (Methyl 4-hydroxycinnamate), an orally active esterified derivative of p-Coumaric acid (pCA), can be isolated from the flower of Trixis michuacana var longifolia. Methyl p-coumarate could inhibit the melanin formation in B16 mouse melanoma cells. Methyl p-coumarate also has strong in vitro inhibitory effect on A. alternata and other pathogens[1][2].

Product Specifications

CAS Number

[3943-97-3]

Product Name Alternative

Methyl 4-hydroxycinnamate

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Fungal

Type

Natural Products

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/methyl-p-coumarate.html

Purity

99.80

Solubility

DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(OC)/C=C/C1=CC=C(O)C=C1

Molecular Formula

C10H10O3

Molecular Weight

178.19

Precautions

H302, H315, H319, H335

References & Citations

[1]Kubo I, et, al. Methyl p-coumarate, a melanin formation inhibitor in B16 mouse melanoma cells. Bioorg Med Chem. 2004 Oct 15;12 (20) :5349-54.|[2]Yuan S, et, al. Defense Responses, Induced by p-Coumaric Acid and Methyl p-Coumarate, of Jujube (Ziziphus jujuba Mill.) Fruit against Black Spot Rot Caused by Alternaria alternate. J Agric Food Chem. 2019 Mar 13;67 (10) :2801-2810.|[3]Park JW, et al. Methyl P-Coumarate Ameliorates the Inflammatory Response in Activated-Airway Epithelial Cells and Mice with Allergic Asthma. Int J Mol Sci. 2022 Nov 28;23 (23) :14909.