UNC0642

UNC0642, a chemical probe, is a potent and selective lysine methyltransferases G9a and GLP inhibitor, with an IC50 of G9a.

Product Specifications

CAS Number

[1481677-78-4]

UNSPSC

12352005

Hazard Statement

H302

Target

Histone Methyltransferase

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/UNC0642.html

Purity

99.86

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

CC(N1CCC(NC2=C3C=C(OC)C(OCCCN4CCCC4)=CC3=NC(N5CCC(F)(F)CC5)=N2)CC1)C

Molecular Formula

C29H44F2N6O2

Molecular Weight

546.70

Precautions

H302

References & Citations

[1]Liu F, et al. Discovery of an in vivo chemical probe of the lysine methyltransferases G9a and GLP. J Med Chem. 2013 Nov 14;56 (21) :8931-8942.|[2]Wang L, et al. Targeting EHMT2 reverses EGFR-TKI resistance in NSCLC by epigenetically regulating the PTEN/AKT signaling pathway. Cell Death Dis. 2018 Jan 26;9 (2) :129