What is the catalog number for Rottlerin?

The catalog number for Rottlerin is HY-18980.

What sizes are available for Rottlerin?

Rottlerin is available in the following size(s): 5 mg, 10 mM - 1 mL, 10 mg, 25 mg.

How many pack sizes does Rottlerin come in?

Rottlerin is available in 4 different pack sizes.

Is Rottlerin in stock?

Rottlerin is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Rottlerin?

Rottlerin is manufactured by QuantiMol.

What is the estimated delivery time for Rottlerin?

Estimated delivery time for Rottlerin is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Rottlerin?

The safety data sheet for Rottlerin is available here: http://file.medchemexpress.com/batch_PDF/HY-18980/Rottlerin-SDS-MedChemExpress.pdf.

Rottlerin

Rottlerin, a natural product purified from Mallotus Philippinensis, is a specific PKC inhibitor, with IC50 values for PKCδ of 3-6 μM, PKCα, β, γ of 30-42 μM, PKCε, η, ζ of 80-100 μM. Rottlerin acts as a direct mitochondrial uncoupler, and stimulates autophagy by targeting a signaling cascade upstream of mTORC1. Rottlerin induces apoptosis via caspase 3 activation[1][2][3]. Rottlerin inhibits HIV-1 integration and Rabies virus (RABV) infection[4][5].

Product Specifications

CAS Number

82-08-6

Product Name Alternative

Mallotoxin; NSC 56346; NSC 94525

UNSPSC

12352005

Hazard Statement

H302+H312+H332, H315, H319, H335

Target

Apoptosis; Autophagy; HIV; PKC; RABV

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis; Autophagy; Epigenetics; TGF-beta/Smad

Applications

COVID-19-immunoregulation

Field of Research

Infection; Cancer

Assay Protocol

https://www.medchemexpress.com/Rottlerin.html

Concentration

10mM

Purity

98.45

Solubility

DMSO : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(C1=C2C(C=CC(C)(C)O2)=C(O)C(CC3=C(O)C(C)=C(O)C(C(C)=O)=C3O)=C1O)/C=C/C4=CC=CC=C4

Molecular Formula

C30H28O8

Molecular Weight

516.54

Precautions

H302+H312+H332, H315, H319, H335

References & Citations

[1]Gschwendt M, et al. Rottlerin, a novel protein kinase inhibitor. Biochem Biophys Res Commun. 1994 Feb 28;199 (1) :93-8.|[2]Valacchi G, et al. Rottlerin exhibits antiangiogenic effects in vitro. Chem Biol Drug Des. 2011 Jun;77 (6) :460-70.|[3]Minzhao Huang, et al. Rottlerin suppresses growth of human pancreatic tumors in nude mice, and pancreatic cancer cells isolated from KrasG12D mice. Cancer Letters 353 (2014) 32-40.|[4]María Rosa López-Huertas, et al. Protein kinase Ctheta is a specific target for inhibition of the HIV type 1 replication in CD4+ T lymphocytes. J Biol Chem. 2011 Aug 5;286 (31) :27363-77.|[5]Zoé Lama, et al. Kinase inhibitors tyrphostin 9 and rottlerin block early steps of rabies virus cycle. Antiviral Res. 2019 Aug;168:51-60.