Anti-Hu CD75 Purified
CD75 is a lactosamine structure, which is present mainly on the surface of germinal center B cells. With lower level it is present on other mature B cells, and it is downregulated during differentiation to plasma cells. It is a marker which differentiates between malignant B cell types.
Product Specifications
Certification
RUO
Reactivity
Human
Immunogen
Stimulated human PBL
Target Antigen
CD75
Clone
LN1
Applications
IHC-P, FC (QC tested), IHC-F
Concentration
1 mg/mL
Format
Purified
Buffer
Tris buffered saline (TBS), pH 8.0, 15 mM sodium azide
References & Citations
*Fromm JR, Thomas A, Wood BL: Characterization and purification of neoplastic cells of nodular lymphocyte predominant hodgkin lymphoma from lymph nodes by flow cytometry and flow cytometric cell sorting. Am J Pathol. 2017 Feb;187 (2) :304-317., URL: https://pubmed.ncbi.nlm.nih.gov/27998726/, *Epstein AL, Marder RJ, Winter JN, Fox RI: Two new monoclonal antibodies (LN-1, LN-2) reactive in B5 formalin-fixed, paraffin-embedded tissues with follicular center and mantle zone human B lymphocytes and derived tumors. J Immunol. 1984 Aug;133 (2) :1028-36., URL: https://pubmed.ncbi.nlm.nih.gov/6376628/, *Virtanen S, Schulte R, Stingl J, Caldas C, Shehata M: High-throughput surface marker screen on primary human breast tissues reveals further cellular heterogeneity. Breast Cancer Res. 2021 Jun 13;23 (1) :66., URL: https://pubmed.ncbi.nlm.nih.gov/34120626/
Storage Conditions
Store at 2-8°C. Do not freeze.
Specificity
The mouse monoclonal antibody LN1 recognizes CD75, a lactosamine structure present mainly on the surface of B cell types.
Applications Notes
Flow cytometry: Recommended dilution: 1-4 μg/ml.
Isotype
Mouse IgM kappa
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