Tolrestat (Standard)
Tolrestat (Standard) is the analytical standard of Tolrestat. This product is intended for research and analytical applications. Tolrestat is a potent, orally active aldose reductase inhibitor with IC50 of 35 nM.
Product Specifications
CAS Number
82964-04-3
Product Name Alternative
AY-27773 (Standard)
UNSPSC
12352005
Target
Aldose Reductase; Reference Standards
Type
Reference Standards
Related Pathways
Metabolic Enzyme/Protease; Others
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tolrestat-standard.html
Smiles
O=C(O)CN(C(C1=C2C=CC(OC)=C(C(F)(F)F)C2=CC=C1)=S)C
Molecular Formula
C16H14F3NO3S
Molecular Weight
357.35
References & Citations
[1]Sestanj K, et al. N-[5- (trifluoromethyl) -6-methoxy-1-naphthalenyl]thioxomethyl]- N-methylglycine (Tolrestat), a potent, orally active aldose reductase inhibitor. J Med Chem. 1984 Mar;27 (3) :255-6.|[2]Simard-Duquesne N, et al. The effects of a new aldose reductase inhibitor (tolrestat) in galactosemic and diabetic rats. Metabolism. 1985 Oct;34 (10) :885-92.|[3]Srivastava S, et al. Aldose reductase protects against early atherosclerotic lesion formation in apolipoprotein E-null mice. Circ Res. 2009 Oct 9;105 (8) :793-802.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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