DAS-5-oCRBN
DAS-5-oCRBN is a selective and potent PROTAC degrader of c-Src kinase. DAS-5-oCRBN has antiproliferative activity in both c-Src-dependent cell lines[1].
Product Specifications
UNSPSC
12352005
Target
PROTACs; Src
Type
Reference compound
Related Pathways
PROTAC; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/das-5-ocrbn.html
Purity
98.75
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC1=C(NC(C2=CN=C(NC3=CC(N4CCN(CC(N5CCN(C6=C7C(N(C8CCC(NC8=O)=O)C(C7=CC=C6)=O)=O)CC5)=O)CC4)=NC(C)=N3)S2)=O)C(Cl)=CC=C1
Molecular Formula
C39H40ClN11O6S
Molecular Weight
826.32
References & Citations
[1]Mao W, et al. Selective and Potent PROTAC Degraders of c-Src Kinase. ACS Chem Biol. 2024 Jan 19;19 (1) :110-116.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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