DAS-5-oCRBN
Product Specifications
UNSPSC Description
DAS-5-oCRBN is a selective and potent PROTAC degrader of c-Src kinase. DAS-5-oCRBN has antiproliferative activity in both c-Src-dependent cell lines[1].
Target Antigen
PROTACs; Src
Type
Reference compound
Related Pathways
PROTAC;Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/das-5-ocrbn.html
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC1=C(NC(C2=CN=C(NC3=CC(N4CCN(CC(N5CCN(C6=C7C(N(C8CCC(NC8=O)=O)C(C7=CC=C6)=O)=O)CC5)=O)CC4)=NC(C)=N3)S2)=O)C(Cl)=CC=C1
Molecular Weight
826.32
References & Citations
[1]Mao W, et al. Selective and Potent PROTAC Degraders of c-Src Kinase. ACS Chem Biol. 2024 Jan 19;19(1):110-116.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-163144/DAS-5-oCRBN-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-163144/DAS-5-oCRBN-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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