HMBPP (lithium)

HMBPP lithium is an intermediate in isoprenoid biosynthesis that can be produced by bacteria and protozoa that use the non-mevalonate pathway for isoprenoid biosynthesis. HMBPP lithium is a ligand of the internal domain of BTN3A1 and is an activator for human Vγ9/Vδ2 T cells. HMBPP lithium exhibits phagostimulant property in mosquitos[1][2][3][4].

Product Specifications

CAS Number

[396726-03-7]

Product Name Alternative

(E) -4-Hydroxy-3-methyl-but-2-enyl diphosphate (lithium)

UNSPSC

12352211

Hazard Statement

H302

Target

Nuclear Factor of activated T Cells (NFAT)

Type

Natural Products

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/hmbpp.html

Purity

98.0

Solubility

10 mM in DMSO

Smiles

O=P(OP(O[Li])(O[Li])=O)(O[Li])OC/C=C(C)/CO

Molecular Formula

C5H9Li3O8P2

Molecular Weight

279.89

Precautions

H302

References & Citations

[1]Hintz M, et al., Identification of (E) -4-hydroxy-3-methyl-but-2-enyl pyrophosphate as a major activator for human gammadelta T cells in Escherichia coli. FEBS Lett. 2001 Dec 7;509 (2) :317-22.|[2]Stromsky VE, et al., Plasmodium metabolite HMBPP stimulates feeding of main mosquito vectors on blood and artificial toxic sources. Commun Biol. 2021 Oct 7;4 (1) :1161.|[3]Rosso DA, et al. Glioblastoma cells potentiate the induction of the Th1-like profile in phosphoantigen-stimulated γδ T lymphocytes. J Neurooncol. 2021 Jul;153 (3) :403-415. |[4]Nguyen K, et al. The butyrophilin 3A1 intracellular domain undergoes a conformational change involving the juxtamembrane region. FASEB J. 2017 Nov;31 (11) :4697-4706. |[5]Huang D, et al. Antigen-specific Vgamma2Vdelta2 T effector cells confer homeostatic protection against pneumonic plaque lesions. Proc Natl Acad Sci U S A. 2009 May 5;106 (18) :7553-8.