1,4-Dicaffeoylquinic acid

1,4-Dicaffeoylquinic acid (1,4-DCQA) is a phenylpropanoid compound that can be isolated from Xanthii fructus and an inhibitor of xanthine oxidase (IC50: 7.36 μM) . 1,4-Dicaffeoylquinic acid has anti-inflammatory activity and can inhibit the production of TNF-α induced by LPS (HY-D1056) [1][2].

Product Specifications

CAS Number

[1182-34-9]

Product Name Alternative

1,4-DCQA

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

TNF Receptor; Xanthine Oxidase

Type

Natural Products

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/1-4-dicaffeoylquinic-acid.html

Purity

99.80

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC1=CC=C(/C=C/C(O[C@H]2[C@H](O)C[C@@](C(O)=O)(OC(/C=C/C3=CC(O)=C(O)C=C3)=O)C[C@H]2O)=O)C=C1O

Molecular Formula

C25H24O12

Molecular Weight

516.45

Precautions

H302, H315, H319, H335

References & Citations

[1]Yoo SR, et al. Phytochemical Analysis on Quantification and the Inhibitory Effects on Inflammatory Responses from the Fruit of Xanthii fructus. Pharmacogn Mag. 2015 Oct;11 (Suppl 4) :S585-91.|[2]Cao W, et al. Insights from multispectral and molecular docking investigation on the xanthine oxidase inhibition by 1, 4-dicaffeoylquinic acid. Journal of Molecular Structure, 2020, 1219: 128475.