Lys05

Lys05 (Lys01 trihydrochloride) is a novel lysosomal autophagy inhibitor with IC50 values of 3.6, 3.8, 6 and 7.9 μM for 1205Lu, c8161, LN229 and HT-29 cell line in the MTT assay.

Product Specifications

CAS Number

[1391426-24-6]

Product Name Alternative

Lys01 (trihydrochloride)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Autophagy

Type

Reference compound

Related Pathways

Autophagy

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Lys01__trihydrochloride_.html

Purity

99.74

Solubility

DMSO : 5.41 mg/mL (ultrasonic) |H2O : 5.83 mg/mL (ultrasonic)

Smiles

CN(CCNC1=CC=NC2=C1C=CC(Cl)=C2)CCNC3=CC=NC4=CC(Cl)=CC=C43.[H]Cl.[H]Cl.[H]Cl

Molecular Formula

C23H26Cl5N5

Molecular Weight

549.75

Precautions

H302, H315, H319, H335

References & Citations

[1]McAfee Q, et al. Autophagy inhibitor Lys05 has single-agent antitumor activity and reproduces the phenotype of a genetic autophagy deficiency. Proc Natl Acad Sci U S A. 2012 May 22;109 (21) :8253-8.