BMS-193885

BMS-193885 is a selective neuropeptide Y1 receptor antagonist (Ki=3.3 nM) that competitively blocks the receptor to inhibit NPY-mediated appetite regulation signaling pathways, reduce food intake and inhibit weight gain. BMS-193885 has good blood-brain barrier penetration and is mainly used in the study of obesity and related metabolic diseases[1][2][3].

Product Specifications

CAS Number

[186185-03-5]

UNSPSC

12352005

Hazard Statement

H302

Target

Neuropeptide Y Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease; Endocrinology

Assay Protocol

https://www.medchemexpress.com/bms-193885.html

Purity

99.91

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=C(C)NC(C)=C(C(OC)=O)C1C2=CC=CC(NC(NCCCN3CCC(C4=CC=CC(OC)=C4)CC3)=O)=C2)OC

Molecular Formula

C33H42N4O6

Molecular Weight

590.71

Precautions

H302

References & Citations

[1]Antal-Zimanyi I, et al. Pharmacological characterization and appetite suppressive properties of BMS-193885, a novel and selective neuropeptide Y (1) receptor antagonist. Eur J Pharmacol. 2008 Aug 20;590 (1-3) :224-32.|[2]Poindexter GS, et al. Dihydropyridine neuropeptide Y Y (1) receptor antagonists. Bioorg Med Chem Lett. 2002 Feb 11;12 (3) :379-82.|[3]Kaczyńska K, et al. NPY Y (1) receptors are involved in cardio-respiratory responses to intravenous injection of neuropeptide Y in anaesthetized rats. Pharmacol Res. 2010 Nov;62 (5) :444-9.