Harmane (hydrochloride)

Harmane hydrochloride is a benzodiazepine receptor inhibitor (IC50=7 μM), with IC50 values for mACh, Opioid Receptor, MAO-A/B, and α2-adrenergic receptor of 24 μM, 2.8 μM, 0.5 μM, 5 μM, and 18 μM, respectively. Harmane hydrochloride inhibits the I1 imidazoline receptor (IC50 = 30 nM) to reduce blood pressure and has antidepressant, anti-anxiety, anticonvulsant, and analgesic effects. Harmane hydrochloride inhibits dopamine biosynthesis by decreasing tyrosine hydroxylase (TH) activity and enhancing L-DOPA-induced cytotoxicity in PC12 cells. Additionally, Harmane hydrochloride can increase the mutagenic effect induced by 2-acetylaminofluorene (AAF) [1][2][3][4][5][6].

Product Specifications

CAS Number

[21655-84-5]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Adrenergic Receptor; GABA Receptor; Imidazoline Receptor; Monoamine Oxidase; nAChR; Opioid Receptor

Type

Natural Products

Related Pathways

GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/harmane-hydrochloride.html

Purity

99.35

Smiles

CC1=NC=CC2=C1NC3=C2C=CC=C3.Cl

Molecular Formula

C12H11ClN2

Molecular Weight

218.68

Precautions

H302, H315, H319, H335

References & Citations

[1]W E Müller, et al. On the neuropharmacology of harmane and other beta-carbolines. Pharmacol Biochem Behav. 1981 May;14 (5) :693-9.|[2]Musgrave IF, et, al. Harmane produces hypotension following microinjection into the RVLM: possible role of I (1) -imidazoline receptors. Br J Pharmacol. 2000 Mar;129 (6) :1057-9.|[3]Glover V, et, al. β-Carbolines as selective monoamine oxidase inhibitors:In vivo implications|[4]https://pubmed.ncbi.nlm.nih.gov/345280/|[5]E D Louis, et al. Harmane induces anxiolysis and antidepressant-like effects in rats. Ann N Y Acad Sci. 2005 Aug 9;65 (3) :391-6.|[6]Yoo Jung Yang, et al. Effects of harman and norharman on dopamine biosynthesis and L-DOPA-induced cytotoxicity in PC12 cells. Eur J Pharmacol. 2008 Jun 10;587 (1-3) :57-64.